Search results for " F-ST"

showing 3 items of 3 documents

Genome-wide association study reveals the locus responsible for microtia in Valle del Belice sheep breed.

2018

Microtia is a congenital deformity of the outer ear with phenotypes varying from a small auricle to total absence (anotia). The genetic basis is still poorly understood, and very few studies have been performed in sheep. Valle del Belice sheep is a breed showing microtia. The aim of this study was to identify the potential genomic regions involved in microtia in sheep. A total of 40 individuals, 20 with microtia and 20 normal, were genotyped with the Illumina OvineSNP50 BeadChip. The comparison among the results from a genome-wide association study, Fisher's exact test and FST analysis revealed a single strong association signal: rs419889303 on chromosome 1, located within intron 3 of the C…

0301 basic medicineCandidate geneGenotypeSheep Diseasesfisher's testLocus (genetics)Genome-wide association studyBiologyBreedingPolymorphism Single NucleotideCLRN1 geneear size03 medical and health sciencesSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoCLRN1 gene fisher's test F-ST genome-wide association studies ear size ovineGeneticsmedicineAnimalsGenetic Association StudiesSheep DomesticCongenital MicrotiaGeneticsSheepF-STMicrotia0402 animal and dairy scienceMembrane ProteinsCLRN1 gene Fisher’s test FST genome-wide association studies ear size ovine04 agricultural and veterinary sciencesGeneral Medicinemedicine.disease040201 dairy & animal scienceBreedCLRN1 geneovineExact test030104 developmental biologyAnotiagenome-wide association studiesAnimal Science and ZoologyAnimal genetics
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Genome-wide assessment of diversity and differentiation between original and modern Brown cattle populations

2020

Identifying genomic regions involved in the differences between breeds can provide information on genes that are under the influence of both artificial and natural selection. The aim of this study was to assess the genetic diversity and differentiation among four different Brown cattle populations (two original vs. two modern populations) and to characterize the distribution of runs of homozygosity (ROH) islands using the Illumina Bovine SNP50 BeadChip genotyping data. After quality control, 34 735 SNPs and 106 animals were retained for the analyses. Larger heterogeneity was highlighted for the original populations. Patterns of genetic differentiation, multidimensional scaling, and the neig…

0301 basic medicineCandidate genecandidate genes FST genetic diversity runs of homozygosityGenotypeBiologyRuns of HomozygosityQuantitative trait locusBreedingGenomePolymorphism Single Nucleotide03 medical and health sciencesGeneticsAnimalsGenotypingGenetic diversityruns of homozygosityNatural selectionF-STHomozygote0402 animal and dairy science04 agricultural and veterinary sciencesGeneral Medicinegenetic diversity040201 dairy & animal science030104 developmental biologyGenetics PopulationPhenotypecandidate genes; F-ST; genetic diversity; runs of homozygosityEvolutionary biologyAnimal Science and ZoologyCattleBrown Swisscandidate genes
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A combined genome-wide approach identifies a new potential candidate marker associated with the coat color sidedness in cattle

2019

Abstract Coat color is one of the most important phenotypic features in livestock breeds. Cinisara is a local cattle breed generally of uniform black color which occasionally presents a particular phenotype, with animals typically display a white band along their spine, from the head to the tail, and on the ventral line (color sidedness). Therefore, this breed provides an ideal model to study the genetic components underlying phenotypic variation in coat color. A total of 63 animals, ten with sidedness phenotype and 53 with uniform black color were genotyped with Illumina Bovine 50 K. The comparison among genome-wide association study and FST analysis revealed a single nucleotide polymorphi…

GeneticsPLK2 geneCandidate geneCoatGeneral VeterinarySingle-nucleotide polymorphismBiologyCoat colorPhenotypeGenomeSTSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoFCoat color GWAS F-ST cattle PLK2 geneGWASSNPCattleAnimal Science and ZoologyGenetic variabilitySettore SECS-S/01 - StatisticaGeneLivestock Science
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